Ginseng32Read the ginseng guide
Ingredient research catalog · Updated July 16, 2026
Research on ginseng, lion’s mane, and whole sesame oil
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Records follow the frozen research-ledger order rather than a promotional ranking. Published preclinical literature may be affected by publication bias.
Red Ginseng Ethanolic Extract Alleviates DSS-Induced Colitis in Mice by Suppressing Inflammatory Mediator Production.
Zhang Peng-Yu et al. · International Journal of Molecular Sciences · 2026 · DOI 10.3390/ijms27125325
Material: Red-ginseng ethanolic extract · Model: DSS-colitis mice and LPS-stimulated RAW264.7 macrophages
Key limit: DSS disease model; extract received only preliminary chemical profiling.
Rice-Fried and Sun-Dried Ginseng: A Comparative Study of Chemical Composition and Protective Effects Against Ulcerative Colitis.
Chu Qi et al. · International Journal of Molecular Sciences · 2026 · DOI 10.3390/ijms27052140
Material: Rice-fried and sun-dried Panax ginseng preparations · Model: DSS-colitis mice and LPS-stimulated Caco-2 cells
Key limit: Processing-specific comparison involving distinct preparations and doses.
Ginseng extract alleviates growth reduction, intestinal barrier damage, and oxidative stress in Lithobates catesbeiana induced by soybean meal
Wu Xiongqi et al. · Aquaculture · 2025 · DOI 10.1016/j.aquaculture.2025.742154
Material: Dietary ginseng extract · Model: Bullfrogs fed a high-soybean-meal diet
Key limit: Aquaculture nutrition model; DOI-only local record with a short manually retained abstract.
Impact of dietary ginseng stem leaf extract on intestinal barrier function, gut microbiota and short-chain fatty acid metabolism in broilers
Zhang Peng et al. · Journal of Applied Animal Research · 2025 · DOI 10.1080/09712119.2025.2539134
Material: Dietary ginseng stem-leaf extract · Model: Broiler chickens
Key limit: Poultry model and stem-leaf extract; DOI-only local record with limited abstract detail.
Korean Red Ginseng alleviates dextran sodium sulfate-induced colitis through gut microbiota modulation in mice.
Jeong Ji-Soo et al. · Journal of Ginseng Research · 2024 · DOI 10.1016/j.jgr.2024.08.001
Material: Korean Red Ginseng, 200 or 400 mg/kg/day · Model: Male C57BL/6 mice with DSS-induced colitis
Key limit: Preventive high-dose DSS model; incomplete material standardization in the main report.
Comparative evaluation of fermented ginseng on alleviating antibiotic-associated diarrhea in mice.
Li Qiuyang et al. · Food Science and Biotechnology · 2024 · DOI 10.1007/s10068-024-01538-8
Material: Fermented red, white and black ginseng · Model: Clindamycin-associated-diarrhea mice
Key limit: Antibiotic-injury model and multiple fermented preparations.
Fermented Cultured Wild Ginseng Roots (Panax ginseng C.A. Meyer) Using Limosilactobacillus fermentum HY7303 Enhances the Intestinal Barrier by Bioconversion of Ginsenosides and Extracellular Vesicle Production
Mo Sung-Joon et al. · Fermentation · 2024 · DOI 10.3390/fermentation10070362
Material: Separately tested unfermented cultured-wild-ginseng roots, fermented ginseng and extracellular-vesicle preparations · Model: LPS-challenged Caco-2 monolayers
Key limit: Cell study; fermentation and extracellular-vesicle effects must not be attributed to plain ginseng.
The protective effects of ginseng on x-irradiation-induced intestinal damage in rats.
Ozdemir Ali et al. · Radiation and Environmental Biophysics · 2023 · DOI 10.1007/s00411-023-01039-y
Material: Korean Red Ginseng administered intraperitoneally · Model: Male Sprague-Dawley rats exposed to x-irradiation
Key limit: Radiation model and non-oral administration.
Effect of fermented red ginseng on gut microbiota dysbiosis- or immobilization stress-induced anxiety, depression, and colitis in mice.
Shin Yoon-Jung et al. · Journal of Ginseng Research · 2023 · DOI 10.1016/j.jgr.2022.08.004
Material: Red ginseng and fermented red ginseng · Model: Immobilization-stressed mice and mice receiving ulcerative-colitis/depression donor feces
Key limit: Complex gut-brain and fecal-transfer models; not a general digestive-wellness study.
Restorative effects of Rg3-enriched Korean Red Ginseng and Persicaria tinctoria extract on oxazolone-induced ulcerative colitis in mice.
Ullah H. M. Arif et al. · Journal of Ginseng Research · 2022 · DOI 10.1016/j.jgr.2021.07.001
Material: Separate Rg3-enriched red-ginseng, Persicaria and combination arms · Model: Oxazolone-colitis mice
Key limit: Multi-arm botanical paper; combination results cannot be assigned to ginseng.
Limosilactobacillus fermentum-fermented ginseng improved antibiotic-induced diarrhoea and the gut microbiota profiles of rats.
Qu Qingsong et al. · Journal of Applied Microbiology · 2022 · DOI 10.1111/jam.15780
Material: Fermented ginseng compared with a bacterium-ginseng mixture · Model: Antibiotic-fed rats
Key limit: Fermented preparation and antibiotic-injury model.
Korean Red Ginseng Extract Inhibits IL-8 Expression via Nrf2 Activation in Helicobacter pylori-Infected Gastric Epithelial Cells.
Kim Hae Sou et al. · Nutrients · 2022 · DOI 10.3390/nu14051044
Material: Korean Red Ginseng extract · Model: H. pylori-infected human AGS gastric epithelial cells
Key limit: Cell study; does not demonstrate H. pylori eradication or clinical treatment.
Effects of red ginseng on gut, microbiota, and brain in a mouse model of post-infectious irritable bowel syndrome.
Yu Seonhye et al. · Journal of Ginseng Research · 2021 · DOI 10.1016/j.jgr.2021.03.008
Material: Red ginseng · Model: Zymosan-induced post-infectious IBS-like mice
Key limit: Mouse symptom model; not mucosal-repair evidence.
Fermented ginseng attenuates lipopolysaccharide-induced inflammatory responses by activating the TLR4/MAPK signaling pathway and remediating gut barrier.
Fan Jingjing et al. · Food & Function · 2021 · DOI 10.1039/d0fo02404j
Material: Lactiplantibacillus plantarum-fermented ginseng, 390 mg/kg/day · Model: LPS-challenged C57BL/6N mice
Key limit: Systemic LPS model and fermented material.
Effects of fermented ginseng on the gut microbiota and immunity of rats with antibiotic-associated diarrhea.
Qu Qingsong et al. · Journal of Ethnopharmacology · 2021 · DOI 10.1016/j.jep.2020.113594
Material: Limosilactobacillus fermentum-fermented ginseng · Model: Sprague-Dawley rats receiving triple antibiotics
Key limit: Antibiotic model; dose response was not uniformly positive.
Alleviation of Ulcerative Colitis Potentially through Th1/Th2 Cytokine Balance by a Mixture of Rg3-Enriched Korean Red Ginseng Extract and Persicaria tinctoria.
Saba Evelyn et al. · Molecules · 2020 · DOI 10.3390/molecules25225230
Material: Independent Rg3-enriched red-ginseng, Persicaria and mixture arms · Model: DSS-colitis C57BL/6 mice and RAW264.7 cells
Key limit: Combination-focused paper; mixture findings cannot be presented as ginseng-only findings.
Red ginseng protects against cisplatin-induced intestinal toxicity by inhibiting apoptosis and autophagy via the PI3K/AKT and MAPK signaling pathways.
Zhang Jun-Jie et al. · Food & Function · 2020 · DOI 10.1039/d0fo00469c
Material: Red-ginseng root preparation, 300 or 600 mg/kg · Model: Cisplatin-injured male ICR mice
Key limit: Chemotherapy-toxicity model and high animal dose.
Inhibitory effect of Korean Red Ginseng extract on DNA damage response and apoptosis in Helicobacter pylori-infected gastric epithelial cells.
Kang Hyunju et al. · Journal of Ginseng Research · 2020 · DOI 10.1016/j.jgr.2018.08.003
Material: Korean Red Ginseng extract · Model: H. pylori-infected AGS gastric epithelial cells
Key limit: Cell study; not evidence of infection clearance.
Fermented Red Ginseng Alleviates Cyclophosphamide-Induced Immunosuppression and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Regulating Macrophage Activation and T Cell Differentiation.
Kim Jeon-Kyung et al. · American Journal of Chinese Medicine · 2018 · DOI 10.1142/S0192415X18500945
Material: Water, ethanol, enzyme-treated and fermented red-ginseng preparations · Model: Cyclophosphamide-immunosuppressed and TNBS-colitis mice
Key limit: Multiple differently processed materials and disease models.
Oral administration of red ginseng powder fermented with probiotic alleviates the severity of dextran-sulfate sodium-induced colitis in a mouse model.
Jang Sun-Hee et al. · Chinese Journal of Natural Medicines · 2017 · DOI 10.1016/S1875-5364(17)30035-3
Material: Probiotic-fermented red-ginseng powder with ginseng-only and probiotic-only comparators · Model: DSS-colitis mice
Key limit: Fermentation product differs materially from unfermented ginseng.
Ginseng Berry Extract Attenuates Dextran Sodium Sulfate-Induced Acute and Chronic Colitis.
Zhang Wei et al. · Nutrients · 2016 · DOI 10.3390/nu8040199
Material: Ginseng-berry extract, 50 mg/kg · Model: Acute and chronic DSS-colitis C57BL/6 mice
Key limit: Berry extract is not equivalent to root material.
Oral administration of fermented wild ginseng ameliorates DSS-induced acute colitis by inhibiting NF-kB signaling and protects intestinal epithelial barrier.
Seong Myeong A et al. · BMB Reports · 2015 · DOI 10.5483/bmbrep.2015.48.7.039
Material: Fermented cultured wild-ginseng root preparation · Model: DSS-colitis mice
Key limit: Fermented wild-ginseng preparation, not ordinary root material.
Red Ginseng and Semen Coicis can improve the structure of gut microbiota and relieve the symptoms of ulcerative colitis.
Guo Mingzhang et al. · Journal of Ethnopharmacology · 2015 · DOI 10.1016/j.jep.2014.12.029
Material: Separately tested red-ginseng and Semen Coicis extracts · Model: TNBS-colitis rats and bacterial-culture experiments
Key limit: Two-botanical paper; results must remain separated by intervention arm.
Korean ginseng modulates the ileal microbiota and mucin gene expression in the growing rat.
Han Kyoung-Sik et al. · Food & Function · 2014 · DOI 10.1039/c4fo00087k
Material: White- or red-ginseng powder in feed · Model: Growing male Sprague-Dawley rats
Key limit: Gene-expression change should not be described as demonstrated mucus production.
ATF-2/CREB/IRF-3-targeted anti-inflammatory activity of Korean red ginseng water extract.
Yang Yanyan et al. · Journal of Ethnopharmacology · 2014 · DOI 10.1016/j.jep.2014.04.008
Material: Korean red-ginseng water extract · Model: RAW264.7/HEK293 cells, ethanol/HCl gastritis in ICR mice and peritonitis in C57BL mice
Key limit: Mixed cell and rodent pharmacology; disease/injury context.
Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils.
Bae Minkyung et al. · Journal of Ginseng Research · 2014 · DOI 10.1016/j.jgr.2013.11.005
Material: Korean Red Ginseng extract · Model: H. pylori-infected Mongolian gerbils
Key limit: Must disclose the absent colonization effect; cannot support an antimicrobial or eradication claim.
Red ginseng extract inhibits the expression of MCP-1 and iNOS in Helicobacter pylori-infected gastric epithelial cells by suppressing the activation of NADPH oxidase and Jak2/Stat3.
Cho Soon Ok et al. · Journal of Ethnopharmacology · 2013 · DOI 10.1016/j.jep.2013.09.013
Material: Standardized Korean red-ginseng extract · Model: H. pylori-infected human AGS gastric epithelial cells
Key limit: Cell mechanism study, not an infection-treatment study.
Ginseng, the root of Panax ginseng C.A. Meyer, protects ethanol-induced gastric damages in rat through the induction of cytoprotective heat-shock protein 27.
Yeo Marie et al. · Digestive Diseases and Sciences · 2008 · DOI 10.1007/s10620-007-9946-6
Material: Two Panax ginseng root extracts · Model: Ethanol-injured rats
Key limit: Preventive acute-injury model; preparation-specific extracts.
Inhibitory activities and attenuated expressions of 5-LOX with red ginseng in Helicobacter pylori-infected gastric epithelial cells.
Park Soojin et al. · Digestive Diseases and Sciences · 2007 · DOI 10.1007/s10620-006-9440-6
Material: Red-ginseng extract · Model: H. pylori-infected human AGS gastric epithelial cells
Key limit: Cell study; no human or eradication outcome.
Rescue of Helicobacter pylori-induced cytotoxicity by red ginseng.
Park Soojin et al. · Digestive Diseases and Sciences · 2005 · DOI 10.1007/s10620-005-2763-x
Material: Red-ginseng extract · Model: H. pylori-infected gastric epithelial cells
Key limit: Cell study; cannot support clinical protection from H. pylori.
Effects of Korean red ginseng extract on cisplatin-induced nausea and vomiting.
Kim Jong-Hoon et al. · Archives of Pharmacal Research · 2005 · DOI 10.1007/BF02969358
Material: Oral Korean red-ginseng total extract · Model: Cisplatin-treated ferrets
Key limit: Chemotherapy side-effect model; functional symptom study, not mucosal or barrier research.
[Pharmacological study on Panax ginseng C. A. Meyer. II. Effects of red ginseng on the experimental gastric ulcer (1)].
Matsuda H; Kubo M · Yakugaku Zasshi · 1984 · DOI 10.1248/yakushi1947.104.5_449
Material: Red-ginseng extract · Model: Experimental gastric-ulcer rats
Key limit: PubMed has no abstract and the full Japanese paper has not been reviewed; no outcome direction is assigned.
Hericium erinaceus Extracts Exert Gastroprotective Effects Through Modulation of the Gut Microbiota and Metabolites.
Bei Ruixin et al. · Food Science & Nutrition · 2026 · DOI 10.1002/fsn3.71851
Material: Fruiting-body alcohol and water extracts · Model: Adult Sprague-Dawley rats, n=6/group, with ethanol-induced gastric injury
Key limit: Preventive high-intensity ethanol model; preparation and dose specific.
Recognition of the impact of Hericium erinaceus mycelium extract on ethanol-damaged gastric epithelial cells using atomic force microscopy.
Jiang Xiaolin et al. · Analytical Methods · 2025 · DOI 10.1039/d5ay00836k
Material: Hericium mycelium extract · Model: Ethanol-damaged human GES-1 gastric epithelial cells
Key limit: Cell-only study; findings are specific to the tested mycelium extract.
The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats.
Durmus Ali et al. · Korean Journal of Internal Medicine · 2021 · DOI 10.3904/kjim.2019.050
Material: Hericium erinaceum preparation; extract/fraction details absent from the indexed abstract · Model: Wistar rats with TNBS-induced colitis
Key limit: Material specification is incomplete in the PubMed abstract.
Therapeutic Effect and Potential Mechanisms of Lion's Mane Medicinal Mushroom, Hericium erinaceus, Mycelia in Submerged Culture on Ethanol-Induced Chronic Gastric Injury.
Mao Xiangjunzhi et al. · International Journal of Medicinal Mushrooms · 2019 · DOI 10.1615/IntJMedMushrooms.2019032885
Material: Whole mycelia produced in submerged culture, 0.5 or 1.0 g/kg · Model: Mouse chronic-and-binge ethanol gastric-injury model
Key limit: High-dose mycelial material.
In Vitro and In Vivo Inhibition of Helicobacter pylori by Ethanolic Extracts of Lion's Mane Medicinal Mushroom, Hericium erinaceus.
Wang Ge et al. · International Journal of Medicinal Mushrooms · 2019 · DOI 10.1615/IntJMedMushrooms.2018029487
Material: Ethanolic Hericium extracts · Model: Six H. pylori strains, infected AGS cells and H. pylori-colonized C57BL mice
Key limit: Disease-adjacent antimicrobial research; cannot support a human eradication or treatment claim.
Extracts from Hericium erinaceus relieve inflammatory bowel disease by regulating immunity and gut microbiota.
Diling Chen et al. · Oncotarget · 2017 · DOI 10.18632/oncotarget.20689
Material: Separately tested polysaccharide, alcohol and whole extracts · Model: TNBS-enema inflammatory-bowel-disease rats
Key limit: Effects from purified fractions must remain separate from whole-extract effects.
Anti-Inflammatory Effects of Ethanol Extract of Lion's Mane Medicinal Mushroom, Hericium erinaceus, in Mice with Ulcerative Colitis.
Qin Mingming et al. · International Journal of Medicinal Mushrooms · 2016 · DOI 10.1615/IntJMedMushrooms.v18.i3.50
Material: Hericium ethanol extract, 250 or 500 mg/kg/day · Model: C57BL/6 mice with DSS-induced acute colitis
Key limit: High-dose DSS disease model.
Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus Extract against Ethanol-Induced Ulcer in Rats.
Wong Jing-Yang et al. · Evidence-Based Complementary and Alternative Medicine · 2013 · DOI 10.1155/2013/492976
Material: Aqueous Hericium fruiting-body extract · Model: Sprague-Dawley rats with ethanol-induced gastric ulcer
Key limit: Pretreatment model with extract- and animal-dose-specific findings.
Different preparation methods of Hericium erinaceus extracts and protection against acute gastric mucosal injury in rats
An Miaoqing et al. · Science and Technology of Food Industry · 2022 · DOI 10.13386/j.issn1002-0306.2021040252
Material: Crude fruiting-body/mycelium polysaccharide, water and fermentation extracts · Model: Female Sprague-Dawley rats, n=12/group, with absolute-ethanol gastric injury
Key limit: Multiple highly preparation-specific extracts.
Hericium erinaceus extract attenuates gastric mucosal injury via Nrf2/HO-1 pathway activation and gut microbiota modulation in rats
Zhu Feng et al. · Journal of Functional Foods · 2025 · DOI 10.1016/j.jff.2025.106842
Material: Hericium erinaceus extract · Model: Ethanol-injured GES-1 cells, preventive ethanol-injury rats and acetic-acid chronic-ulcer rats
Key limit: Multi-model extract study; material specification was limited and dosing varied by model.
Protective Effect of the Ethanol Extract from Hericium erinaceus Against Ethanol-Induced Gastric Ulcers
Lv Guoying et al. · Polish Journal of Food and Nutrition Sciences · 2021 · DOI 10.31883/pjfns/141560
Material: Fruiting-body ethanol extract, 0.625, 1.25 or 2.5 g/kg · Model: Ethanol-ulcer mice, n=10/group
Key limit: Gram-per-kilogram pretreatment doses.
Effect of Culinary-Medicinal Lion's Mane Mushroom, Hericium erinaceus, on Ethanol-Induced Gastric Ulcers in Rats
Abdulla Mahmood et al. · International Journal of Medicinal Mushrooms · 2008 · DOI 10.1615/IntJMedMushr.v10.i4.40
Material: Freeze-dried whole fruiting-body material, 250 or 500 mg/kg · Model: Male Sprague-Dawley rats with absolute-ethanol gastric injury
Key limit: Whole-fruiting-body material studied in a high-dose acute animal-injury model.
Effect of sesame oil on acidified ethanol-induced gastric mucosal injury in rats.
Hsu Dur-Zong; Chu Pei-Yi; Liu Ming-Yie · JPEN Journal of Parenteral and Enteral Nutrition · 2009 · DOI 10.1177/0148607108327046
Material: Orally administered whole sesame oil · Model: Rats with acidified-ethanol acute gastric injury
Key limit: Acute pretreatment model; oil specification was incomplete and dosing was model-specific.
Sesame oil accelerates healing of 2,4,6-trinitrobenzenesulfonic acid-induced acute colitis by attenuating inflammation and fibrosis.
Periasamy Srinivasan et al. · JPEN Journal of Parenteral and Enteral Nutrition · 2013 · DOI 10.1177/0148607112468768
Material: Oral whole sesame oil, 4 mL/kg for seven days after induction · Model: Rats with TNBS-induced acute colitis
Key limit: High-dose animal disease model; same research group as S-01, not an independent-team replication.
Supplementation with sesame oil suppresses genotoxicity, hepatotoxicity and enterotoxicity induced by sodium arsenite in rats.
Akinrinde Akinleye Stephen et al. · Lipids in Health and Disease · 2023 · DOI 10.1186/s12944-022-01760-5
Material: Whole sesame-seed oil, 4 mL/kg · Model: Wistar rats exposed to sodium arsenite
Key limit: Chemical-toxicity co-treatment model, not ordinary digestive-wellness research.
The Healing Effect of Grape Seed Oil Enema with or without Sesame Oil in Acetic Acid Induced Ulcerative Colitis of Rats.
Hosseinzadeh Fatemeh et al. · World Journal of Plastic Surgery · 2017
Material: Sesame-oil or grape-seed-oil enemas · Model: Rats with acetic-acid-induced colitis
Key limit: Non-oral route and internal result conflict; must not be presented as either a clean positive or clean null result.
Sesame Oil Has Gastroprotective And Anti-Oxidative Properties: An Experimental Study In Rats With Indomethacin-Induced Gastric Ulcers.
Hanci Nurulhunda et al. · Eurasian Journal of Food Science and Technology · 2018
Material: Whole sesame oil at two doses · Model: Rats with indomethacin-induced gastric ulcers
Key limit: Non-PubMed journal record; oil specification and exposure details are limited.
Oral Grapeseed Oil and Sesame Oil in Experimental Acetic Acid-Induced Ulcerative Colitis in Rat.
Hosseinzadeh Fatemeh et al. · Annals of Colorectal Research · 2016 · DOI 10.17795/acr-37285
Material: Independent oral sesame-oil, grape-seed-oil and combination arms · Model: Eighty male rats across eight acetic-acid-colitis intervention groups
Key limit: Multi-arm oil study; should be shown as mixed rather than favorable.
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