GF-1R / Ingredient dossier

Lion's mane research in context

The catalog maps 12 non-human lion's-mane publications across varied materials and models. It does not establish that those materials match GF-1R or produce a finished-product human outcome.

Prepared by
Vitality Lab Editorial
Updated
Status
Evidence dossier
Type
Ingredient-level research

01 / GF-1R ingredient

Lion's mane research depends on the material

GF-1R contains lion's mane, while the catalog includes fruiting-body, mycelial, aqueous, ethanol, polysaccharide, fermentation, and whole-material preparations.

Hericium erinaceus is a species name, not a complete material specification. Fruiting body versus mycelium, extraction solvent, fraction, dose, route, and study model affect what a publication can support.

A result from a concentrated extract or high-dose animal model should not be restated as a result from an unspecified lion's-mane ingredient or the finished GF-1R formula.

02 / Frozen ingredient catalog

12 non-human publications

The frozen catalog groups 12 lion's-mane publications using animal, cell, or ex-vivo models. The studies examine gastric and intestinal tissues under preparation-specific experimental conditions.

The count does not represent human clinical trials, independent replications, or twelve studies of GF-1R.

03 / Model examples

Cell and animal models answer different questions

A mycelium extract in damaged gastric epithelial cells and an aqueous fruiting-body extract in an ethanol-injury rat model are distinct forms of evidence.

One cataloged cell study used a lion's-mane mycelium extract with ethanol-damaged human GES-1 gastric epithelial cells. A separate animal study used an aqueous fruiting-body extract before an acute ethanol-induced gastric-ulcer challenge in rats.

Neither design demonstrates a normal-use human outcome, and neither material should be assumed to match GF-1R without a verified specification comparison.

Source register

Sources and further reading

  1. 01

    Primary research / gastric cell model

    Recognition of the impact of Hericium erinaceus mycelium extract on ethanol-damaged gastric epithelial cells using atomic force microscopy

    Cell-only research using ethanol-damaged human GES-1 gastric epithelial cells and a mycelium extract.

  2. 02

    Primary research / animal model

    Gastroprotective Effects of Lion's Mane Mushroom Hericium erinaceus Extract against Ethanol-Induced Ulcer in Rats

    Acute pretreatment rat model using an aqueous fruiting-body extract; not human clinical evidence.